||Recombinant fragment of Human PKLR with N terminal proprietary tag, 41kDa.
||The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
||Lyophilised:Add 100ul of distilled water.
||pH: 6.80Constituents:1.58% Tris HCl, 4% SDS, 3.09% DTT, 0.2% Bromophenol blue, 20% Sucrose
||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
||Belongs to the pyruvate kinase family.