Recombinant Human PLA2G1B, His-tagged
Cat.No. : | PLA2G1B-31023TH |
Product Overview : | Recombinant full length protein, corresponding to amino acids 23-148 of Human PLA2G1B, with an N-Terminal 16 amino acid His tag. |
- Specification
- Gene Information
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Description : | Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al. |
Conjugation : | HIS |
Source : | E. coli |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: None0.05M Acetate buffer pH 4.0 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MRGSHHHHHH GMASHMAVWQ FRKMIKCVIP GSDPFLEYNNYGCYCGLGGS GTPVDELDKC CQTHDNCYDQ AKKLDSCKFLLDNPYTHTYS YSCSGSAITC SSKNKECEAF ICNCDRNAAICFSKAPYNKA HKNLDTKKYC QS |
Sequence Similarities : | Belongs to the phospholipase A2 family. |
Gene Name : | PLA2G1B phospholipase A2, group IB (pancreas) [ Homo sapiens ] |
Official Symbol : | PLA2G1B |
Synonyms : | PLA2G1B; phospholipase A2, group IB (pancreas); PLA2, PLA2A, PPLA2; phospholipase A2; |
Gene ID : | 5319 |
mRNA Refseq : | NM_000928 |
Protein Refseq : | NP_000919 |
MIM : | 172410 |
Uniprot ID : | P04054 |
Chromosome Location : | 12q23-qter |
Pathway : | Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Ether lipid metabolism, organism-specific biosystem; Ether lipid metabolism, conserved biosystem; Fat digestion and absorption, organism-specific biosystem; |
Function : | bile acid binding; calcium ion binding; calcium ion binding; calcium-dependent phospholipase A2 activity; cell surface binding; |
Products Types
◆ Recombinant Protein | ||
PLA2G1B-291H | Recombinant Human PLA2G1B Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Pla2g1b-4898M | Recombinant Mouse Pla2g1b Protein, Myc/DDK-tagged | +Inquiry |
PLA2G1B-3867H | Recombinant Human PLA2G1B Protein, His (Fc)-Avi-tagged | +Inquiry |
PLA2G1B-4147R | Recombinant Rat PLA2G1B Protein, His (Fc)-Avi-tagged | +Inquiry |
Pla2g1b-1185M | Recombinant Mouse Pla2g1b protein(Met1-Cys146), His-tagged | +Inquiry |
◆ Lysates | ||
PLA2G1B-2200HCL | Recombinant Human PLA2G1B cell lysate | +Inquiry |
PLA2G1B-2033MCL | Recombinant Mouse PLA2G1B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPLA2G1B is associated with atherosclerosis and other cardiovascular conditions due to its involvement in lipid metabolism and inflammation.
Modulating PLA2G1B activity could be explored for potential neuroprotective effects, given its involvement in processes related to neuroinflammation.
Dysregulation of PLA2G1B has been linked to inflammatory disorders, cardiovascular diseases, and certain cancers.
Yes, targeting PLA2G1B may be a potential therapeutic strategy for inflammatory diseases, as it plays a role in the production of inflammatory mediators.
Inhibiting PLA2G1B may be explored as a therapeutic approach in cancer treatment by disrupting lipid metabolism and inhibiting cancer cell proliferation.
Customer Reviews (3)
Write a reviewIts exceptional purity and stability make it an ideal choice for a wide range of applications, ensuring reliable and reproducible results.
The PLA2G1B protein comes highly recommended for its exceptional performance in various research applications.
Its unique characteristics contribute to obtaining clear and detailed structural information, allowing researchers to gain insights into protein interactions and conformational changes.
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