Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human PLA2G1B, His-tagged

Cat.No. : PLA2G1B-31023TH
Product Overview : Recombinant full length protein, corresponding to amino acids 23-148 of Human PLA2G1B, with an N-Terminal 16 amino acid His tag.
  • Specification
  • Gene Information
  • Related Products
Description : Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al.
Conjugation : HIS
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: None0.05M Acetate buffer pH 4.0
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MRGSHHHHHH GMASHMAVWQ FRKMIKCVIP GSDPFLEYNNYGCYCGLGGS GTPVDELDKC CQTHDNCYDQ AKKLDSCKFLLDNPYTHTYS YSCSGSAITC SSKNKECEAF ICNCDRNAAICFSKAPYNKA HKNLDTKKYC QS
Sequence Similarities : Belongs to the phospholipase A2 family.
Gene Name : PLA2G1B phospholipase A2, group IB (pancreas) [ Homo sapiens ]
Official Symbol : PLA2G1B
Synonyms : PLA2G1B; phospholipase A2, group IB (pancreas); PLA2, PLA2A, PPLA2; phospholipase A2;
Gene ID : 5319
mRNA Refseq : NM_000928
Protein Refseq : NP_000919
MIM : 172410
Uniprot ID : P04054
Chromosome Location : 12q23-qter
Pathway : Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Ether lipid metabolism, organism-specific biosystem; Ether lipid metabolism, conserved biosystem; Fat digestion and absorption, organism-specific biosystem;
Function : bile acid binding; calcium ion binding; calcium ion binding; calcium-dependent phospholipase A2 activity; cell surface binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is PLA2G1B involved in cardiovascular diseases? 07/01/2020

PLA2G1B is associated with atherosclerosis and other cardiovascular conditions due to its involvement in lipid metabolism and inflammation.

Are there potential neuroprotective effects of modulating PLA2G1B activity? 12/19/2019

Modulating PLA2G1B activity could be explored for potential neuroprotective effects, given its involvement in processes related to neuroinflammation.

In what diseases is PLA2G1B dysregulation observed? 07/30/2018

Dysregulation of PLA2G1B has been linked to inflammatory disorders, cardiovascular diseases, and certain cancers.

Can PLA2G1B be a therapeutic target for inflammatory conditions? 11/10/2017

Yes, targeting PLA2G1B may be a potential therapeutic strategy for inflammatory diseases, as it plays a role in the production of inflammatory mediators.

Can PLA2G1B inhibitors be used for treating cancer? 09/18/2017

Inhibiting PLA2G1B may be explored as a therapeutic approach in cancer treatment by disrupting lipid metabolism and inhibiting cancer cell proliferation.

Customer Reviews (3)

Write a review
Reviews
03/12/2020

    Its exceptional purity and stability make it an ideal choice for a wide range of applications, ensuring reliable and reproducible results.

    10/16/2017

      The PLA2G1B protein comes highly recommended for its exceptional performance in various research applications.

      01/09/2016

        Its unique characteristics contribute to obtaining clear and detailed structural information, allowing researchers to gain insights into protein interactions and conformational changes.

        Ask a Question for All PLA2G1B Products

        Required fields are marked with *

        My Review for All PLA2G1B Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends