Recombinant Human PLAU

• Cat.No.: PLAU-30029TH
• Product Overview: Recombinant fragment, corresponding to amino acids 21-177 of Human Urokinase expressed in insect cells. Predicted mwt: 18 kDa; observed mwt: 54 kDa

Specification

• Description: This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimers disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Tissue specificity: Expressed in the prostate gland and prostate cancers.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 0.02% Sodium AzideConstituents: 0.1M Sodium chloride, 0.05M Sodium acetate, 1mM EDTA, pH 5.0
• Storage: Store at +4°C.
• Sequence Similarities: Belongs to the peptidase S1 family.Contains 1 EGF-like domain.Contains 1 kringle domain.Contains 1 peptidase S1 domain.

Gene Information

• Gene Name: PLAU plasminogen activator, urokinase [ Homo sapiens ]
• Official Symbol: PLAU
• Synonyms: PLAU; plasminogen activator, urokinase; urokinase-type plasminogen activator; UPA; URK
• Gene ID: 5328
• mRNA Refseq: NM_001145031
• Protein Refseq: NP_001138503
• MIM: 191840
• Uniprot ID: P00749
• Chromosome Location: 10q24
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem
• Function: peptidase activity; protein binding; serine-type endopeptidase activity