||Recombinant fragment, corresponding to amino acids 21-177 of Human Urokinase expressed in insect cells. Predicted mwt: 18 kDa; observed mwt: 54 kDa;
||This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimers disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
||Expressed in the prostate gland and prostate cancers.
||>95% by SDS-PAGE
||Preservative: 0.02% Sodium AzideConstituents: 0.1M Sodium chloride, 0.05M Sodium acetate, 1mM EDTA, pH 5.0
||Store at +4°C.
||Belongs to the peptidase S1 family.Contains 1 EGF-like domain.Contains 1 kringle domain.Contains 1 peptidase S1 domain.