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Recombinant Human PLK1, His-tagged

Cat.No.: PLK1-30909TH
Product Overview: Recombinant full length human PLK1, expressed using baculovirus in Sf9 insect cells using an N-terminal His tag.
Description: Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene.
Conjugation: HIS
Tissue specificity: Placenta and colon.
Biological activity: Specific activity 17nmol/min/mg.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.2mM DTT, 0.1mM PMSF, pH 7.0
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.Contains 2 POLO box domains.Contains 1 protein kinase domain.
Gene Name: PLK1 polo-like kinase 1 [ Homo sapiens ]
Official Symbol: PLK1
Synonyms: PLK1; polo-like kinase 1; PLK, polo like kinase (Drosophila); serine/threonine-protein kinase PLK1;
Gene ID: 5347
mRNA Refseq: NM_005030
Protein Refseq: NP_005021
MIM: 602098
Uniprot ID: P53350
Chromosome Location: 16p
Pathway: APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem;
Function: ATP binding; anaphase-promoting complex binding; nucleotide binding; protein binding; protein kinase activity;

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