Recombinant Human POLE3, His-tagged

• Cat.No.: POLE3-28362TH
• Product Overview: Recombinant full length protein, His-Tag at N terminus (Human).

Specification

• Description: POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 0.002% Sodium AzideConstituents: 3mM Sodium chloride, 2.5mM Imidazole, 10mM Tris, pH 8
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) [ Homo sapiens ]
• Official Symbol: POLE3
• Synonyms: POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit); DNA polymerase epsilon subunit 3; arsenic transactivated protein; CHARAC17; CHRAC17; chromatin accessibility complex 17; DNA polymerase epsilon p17 subunit; histone fold protein CHRAC17; p17; Ybl1
• Gene ID: 54107
• mRNA Refseq: NM_017443
• Protein Refseq: NP_059139
• MIM: 607267
• Uniprot ID: Q9NRF9
• Chromosome Location: 9q33
• Pathway: Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; DNA polymerase epsilon complex, organism-specific biosystem; DNA replication, organism-specific biosystem; DNA replication, conserved biosystem
• Function: DNA-directed DNA polymerase activity; nucleotidyltransferase activity; protein binding; sequence-specific DNA binding; transferase activity