Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human PPARG

Cat.No. : PPARG-28670TH
Product Overview : Recombinant fragment, corresponding to amino acids 204-477 of Human PPAR gamma with proprietary tag, approximately 54kDa.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
Source : E. coli
Tissue specificity : Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.
Gene Name : PPARG peroxisome proliferator-activated receptor gamma [ Homo sapiens ]
Official Symbol : PPARG
Synonyms : PPARG; peroxisome proliferator-activated receptor gamma; peroxisome proliferative activated receptor, gamma; NR1C3; PPARG1; PPARG2; PPARgamma;
Gene ID : 5468
mRNA Refseq : NM_005037
Protein Refseq : NP_005028
MIM : 601487
Uniprot ID : P37231
Chromosome Location : 3p25
Pathway : Adipogenesis, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem;
Function : DNA binding; activating transcription factor binding; arachidonic acid binding; drug binding; enzyme binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How many isoforms of PPARG are there, and what are their weights? 04/07/2022

PPARG has two isoforms, PPARG1 (57 kDa) and PPARG2, a splice variant with an additional 30 amino acids at the N-terminus.

What is the molecular weight of PPARG? 12/16/2021

PPARG has two isoforms with molecular weights of 57 kDa and 54 kDa. Modified PPARG is about 67 kDa.

What does PPARG stand for? 02/02/2021

PPARG stands for Peroxisome Proliferator-Activated Receptor Gamma.

Is there a mitochondria-localized form of PPARG? 01/21/2021

Yes, experimental data suggests a 45 kDa protein immunologically related to PPARG, called mt-PPAR, is located in mitochondria. Its molecular weight is less than PPARG2.

What is the role of PPARG in cellular function? 12/20/2019

PPARG is a ligand-activated transcription factor that plays a crucial role in regulating lipid homeostasis, adipogenesis, insulin resistance, and organ development.

What are the known diseases associated with PPARG defects? 11/10/2017

Defects in PPARG are associated with familial partial lipodystrophy type 3 (FPLD3), susceptibility to obesity, type 2 insulin-resistant diabetes, hypertension, and colon cancer.

Where is PPARG mainly localized? 03/19/2017

PPARG is mainly localized in the nucleus, although it can also be detected in the cytoplasm, exhibiting extra-nuclear/non-genomic actions in certain contexts.

Customer Reviews (3)

Write a review
Reviews
09/15/2020

    It was reassuring to use a product that adhered to green chemistry principles, reducing our impact on the environment.

    06/03/2017

      The company's dedication to environmental sustainability reflected positively on the product and our research initiatives.

      05/04/2017

        We appreciated the option to request modifications or custom formulations to meet our project's requirements.

        Ask a Question for All PPARG Products

        Required fields are marked with *

        My Review for All PPARG Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends