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Recombinant Human PPIA

Cat.No. : PPIA-26337TH
Product Overview : Recombinant Full Length Human Cyclophilin A produced in Saccharomyces cerevisiae; amino acids 1-165; 165 amino acids, 18kDa.
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  • Gene Information
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Description : This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE
Sequence Similarities : Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.Contains 1 PPIase cyclophilin-type domain.
Gene Name : PPIA peptidylprolyl isomerase A (cyclophilin A) [ Homo sapiens ]
Official Symbol : PPIA
Synonyms : PPIA; peptidylprolyl isomerase A (cyclophilin A); peptidyl-prolyl cis-trans isomerase A; CYPA;
Gene ID : 5478
mRNA Refseq : NM_021130
Protein Refseq : NP_066953
MIM : 123840
Uniprot ID : P62937
Chromosome Location : 7p13
Pathway : APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystem; Basigin interactions, organism-specific biosystem; Binding and entry of HIV virion, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Early Phase of HIV Life Cycle, organism-specific biosystem;
Function : isomerase activity; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; unfolded protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can PPIA be used as a therapeutic target for infectious diseases? 10/17/2022

PPIA has been studied in the context of infectious diseases, particularly in viral infections, as a potential therapeutic target.

Are there any side effects associated with drugs that target PPIA? 07/07/2022

Some drugs targeting PPIA may have side effects, including immunosuppression, which needs to be carefully managed.

Is PPIA used in organ transplantation procedures? 07/04/2021

Yes, PPIA has been studied in the context of organ transplantation due to its role in immune responses and immunosuppression.

Can PPIA be used as a potential drug target for neuroprotective therapies? 04/09/2019

PPIA modulation has shown promise in neuroprotection, making it a potential drug target for neurodegenerative disorders.

Are there any drugs that target PPIA for clinical use? 05/11/2017

Some drugs, such as cyclosporine, target PPIA for immunosuppressive purposes in transplantation and autoimmune diseases.

Customer Reviews (3)

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Reviews
03/04/2022

    The PPIA protein's robustness and stability have contributed significantly to the success of my experiments, enabling precise and reproducible measurements.

    05/31/2020

      I highly recommend the PPIA protein for a wide range of research applications.

      06/16/2019

        Its exceptional performance, in combination with its clear and distinct protein bands, make it an absolute must-have for researchers looking to achieve accurate and reliable results in their experiments.

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