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Recombinant Human PPM1G, His-tagged

Cat.No. : PPM1G-31050TH
Product Overview : Recombinant fragment, corresponding to amino acids 25-420 of Human PPM1G fused to His-tag at N-terminus, 27 kDa.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression.
Conjugation : HIS
Source : E. coli
Tissue specificity : Widely expressed. Most abundant in testis, skeletal muscle, and heart.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 25mM Tris, 2mM Beta mercaptoethanol, 1mM DTT, 1mM EDTA, pH 7.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MEGKEEPGSD SGTTAVVALI RGKQLIVANA GDSRCVVSEA GKALDMSYDH KPEDEVELAR IKNAGGKVTM DGRVNGGLNL SRAIGDHFYK RNKNLPPEEQ MISALPDIKV LTLTDDHEFM VIACDGIWNV MSSQEVVDFI QSKISQRDEN GELRLLSSIV EELLDQCLAP DTSGDGTGCD NMTCIIICFK PRNTAELQPE SGKRKLEEVL STEGAEENGN SDKKKKAKRD
Sequence Similarities : Belongs to the PP2C family.
Gene Name : PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G [ Homo sapiens ]
Official Symbol : PPM1G
Synonyms : PPM1G; protein phosphatase, Mg2+/Mn2+ dependent, 1G; protein phosphatase 1G (formerly 2C), magnesium dependent, gamma isoform; protein phosphatase 1G; PP2C; gamma; PP2CG; PP2Cgamma; protein phosphatase 2C; gamma isoform;
Gene ID : 5496
mRNA Refseq : NM_177983
Protein Refseq : NP_817092
MIM : 605119
Uniprot ID : O15355
Chromosome Location : 2p23.3
Pathway : mRNA processing, organism-specific biosystem;
Function : hydrolase activity; metal ion binding; protein serine/threonine phosphatase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can PPM1G be targeted for cancer treatment? 08/15/2022

Research is ongoing to explore the therapeutic potential of targeting PPM1G in cancer. Inhibiting or modulating its activity may be a strategy for cancer therapy.

Are there any known associations between PPM1G and cancer? 04/09/2022

Yes, abnormal expression of PPM1G has been linked to certain cancers, suggesting its potential role as a biomarker or therapeutic target.

Are there any genetic disorders associated with PPM1G mutations? 08/25/2020

While rare, mutations in the PPM1G gene have been reported and may be associated with certain genetic disorders. Further research is needed to understand the implications.

How does PPM1G contribute to DNA repair mechanisms? 12/30/2018

PPM1G is involved in the regulation of DNA repair processes, influencing the repair of damaged DNA and maintaining genomic stability.

Can PPM1G be used as a diagnostic marker for specific diseases? 03/13/2016

PPM1G expression levels may serve as a diagnostic marker for certain diseases, including some cancers, but more studies are required to establish its diagnostic utility.

Customer Reviews (3)

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Reviews
11/14/2022

    PPM1G protein's utility in protein electron microscopy structure analysis is commendable.

    12/03/2019

      It enables researchers to delve deeper into the intricacies of protein behavior and aids in advancing our knowledge in various fields, such as molecular biology, biochemistry, and structural biology.

      11/11/2019

        It demonstrates excellent performance in ELISA assays, making it an ideal choice for researchers studying protein-protein interactions, antibody detection, or biomarker identification.

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