Recombinant Human PRKCI
Cat.No. : | PRKCI-28942TH |
Product Overview : | Recombinant full length protein,(amino acids 2-587) of Human PKC iota/lambda, with an N terminal tag.Expressed in a Baculovirus infected Sf9 cell expression system. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. |
Tissue specificity : | Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers. |
Biological activity : | 35 U/ug. One unit is defined as the amount of enzyme that will phosphorylate 1 pmol of Ser/Thr 7 peptide substrate per minute at pH 7.4 and 30°C. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, 10mM reduced Glutathione, pH 8.0 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 OPR domain.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 protein kinase domain. |
Gene Name : | PRKCI protein kinase C, iota [ Homo sapiens ] |
Official Symbol : | PRKCI |
Synonyms : | PRKCI; protein kinase C, iota; DXS1179E; protein kinase C iota type; PKCI; |
Gene ID : | 5584 |
mRNA Refseq : | NM_002740 |
Protein Refseq : | NP_002731 |
MIM : | 600539 |
Uniprot ID : | P41743 |
Chromosome Location : | 3q26.3 |
Pathway : | Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Endocytosis, organism-specific biosystem; |
Function : | ATP binding; metal ion binding; nucleotide binding; phospholipid binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
Prkci-5122M | Recombinant Mouse Prkci Protein, Myc/DDK-tagged | +Inquiry |
PRKCI-4341R | Recombinant Rat PRKCI Protein, His (Fc)-Avi-tagged | +Inquiry |
PRKCI-01H | Recombinant Human PRKCI protein, His-tagged | +Inquiry |
PRKCI-4682R | Recombinant Rat PRKCI Protein | +Inquiry |
PRKCI-2973C | Recombinant Chicken PRKCI | +Inquiry |
◆ Lysates | ||
PRKCI-2854HCL | Recombinant Human PRKCI 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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