"PSMD3" Related Products

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Recombinant Human PSMD3

Cat.No.: PSMD3-30427TH
Product Overview: Recombinant fragment of Human Proteasome 19S S3 with a N terminal proprietary tag; Predicted MWt 36.63 kDa.
Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid.
Protein length: 100 amino acids
Molecular Weight: 36.630kDa inclusive of tags
Source: Wheat germ
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: EFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP
Sequence Similarities: Belongs to the proteasome subunit S3 family.Contains 1 PCI domain.
Gene Name: PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [ Homo sapiens ]
Official Symbol: PSMD3
Synonyms: PSMD3; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; tissue specific transplantation antigen 2 , TSTA2; 26S proteasome non-ATPase regulatory subunit 3; P58; Rpn3; S3;
Gene ID: 5709
mRNA Refseq: NM_002809
Protein Refseq: NP_002800
Uniprot ID: O43242
Chromosome Location: 17q21.2
Pathway: APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem;
Function: binding; enzyme regulator activity;

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