Recombinant Human PTPN6
Cat.No. : | PTPN6-31401TH |
Product Overview : | Recombinant full length Human SHP1 with N-terminal proprietary tag, 95 kDa. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. |
Source : | E. coli |
Biological activity : | Specific Activity: 1 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8.0 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Gene Name : | PTPN6 protein tyrosine phosphatase, non-receptor type 6 [ Homo sapiens ] |
Official Symbol : | PTPN6 |
Synonyms : | PTPN6; protein tyrosine phosphatase, non-receptor type 6; tyrosine-protein phosphatase non-receptor type 6; HCP; HCPH; PTP 1C; SHP 1; SHP1; |
Gene ID : | 5777 |
mRNA Refseq : | NM_002831 |
Protein Refseq : | NP_002822 |
MIM : | 176883 |
Uniprot ID : | P29350 |
Chromosome Location : | 12p13.31 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; |
Function : | hydrolase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; |
Products Types
◆ Recombinant Protein | ||
PTPN6-0698H | Recombinant Human PTPN6 Protein (M1-K595), His/Strep tagged | +Inquiry |
PTPN6-1802H | Recombinant Human PTPN6 Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPN6-4494R | Recombinant Rat PTPN6 Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPN6-0697H | Recombinant Human PTPN6 Protein (M1-K595), Tag Free | +Inquiry |
PTPN6-3129H | Recombinant Human PTPN6 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
PTPN6-001MCL | Recombinant Mouse PTPN6 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPTPN6 acts as a phosphatase, removing phosphate groups from specific tyrosine residues in signaling molecules, thereby downregulating immune cell activation.
Yes, PTPN6 modulation is being explored as a potential target for immunotherapies aimed at enhancing or suppressing immune responses based on the clinical context.
PTPN6 negatively regulates T cell receptor signaling, and its modulation can have implications in controlling excessive immune responses seen in autoimmune diseases.
Yes, PTPN6 is being studied in diseases like rheumatoid arthritis, lupus, and certain types of leukemia and lymphoma.
Researchers are exploring small molecule inhibitors and gene therapies to modulate PTPN6 activity, with potential applications in autoimmune disorders and cancer treatment.
Customer Reviews (3)
Write a reviewStructural biology researchers can leverage its properties to better understand the three-dimensional architecture and conformational changes of proteins, gaining valuable insights into their function and interactions.
PTPN6 protein is highly recommended for various research applications, including ELISA and protein electron microscopy structure analysis.
PTPN6 protein might have biomarker properties, meaning its levels or activity could be indicative of disease progression or treatment response.
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