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Recombinant Human RARA, His-tagged

Cat.No.: RARA-31053TH
Product Overview: Recombinant Human RARA(154-462) was expressed in E.coli. The His-tag recombinant protein is purified by affinity chromatography in combination with FPLC columns. The purified RAR-alpha-LBD is greater than 95% homogeneous based on SDS-PAGE analysis.
Description: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
Source: E.coli
Species: Human
Tag: His
Form: The protein is in 20mM Tris-HCl pH7.9,100mM NaCl, 0.2mM EDTA, 1mM DTT and 20% glycerol.
Molecular Mass: 36.4 kDa
AA Sequence: SKESVRNDRN KKKKEVPKPE CSESYTLTPE VGELIEKVRK AHQETFPALC QLGKYTTNNSSEQRVSLDID LWDKFSELST KCIIKTVEFA KQLPGFTTLT IADQITLLKA ACLDILILRICTRYTPEQDT MTFSDGLTLN RTQMHNAGFG PLTDLVFAFA NQLLPLEMDD AETGLLSAICLICGDRQDLE QPDRVDMLQE PLLEALKVYV RKRRPSRPHM FPKMLMKITD LRSISAKGAERVITLKMEIP GSMPPLIQEM LENSEGLDTL SGQPGGGGRD GGGLAPPPGS CSPSLSPSSNRSSPATHSP
Unit Definition: 1 unit equals 1 nanogram of purified protein. 20 unit is sufficient for a gel mobility shift assay; 100 units are sufficient for protein-protein interaction assays.
Applications: RARα can be applied in in vitro transcription assays, DNA-protein and protein-protein interaction assays.
Storage: Stored at -70°C before use. Avoid repeated freeze thaw cycles.
Gene Name: RARA retinoic acid receptor, alpha [ Homo sapiens (human) ]
Official Symbol: RARA
Synonyms: RARA; NR1B1; RAR; RAR-alpha; Retinoic acid receptor, alpha; Retinoic acid receptor alpha; OTTHUMP00000164454; OTTHUMP00000164456; Nuclear receptor subfamily 1 group B member 1; Retinoic acid receptor, alpha polypeptide; retinoic acid receptor, alpha; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; Retinoic acid receptor alpha (RAR-alpha); NR1B1 (nuclear receptor subfamily 1, group B, member 1)
Gene ID: 5914
mRNA Refseq: NM_000964
Protein Refseq: NP_000955
MIM: 180240
UniProt ID: P10276
Chromosome Location: 17q21
Pathway: Acute myeloid leukemia; Pathways in cancer; IL-3 Signaling Pathway
Function: metal ion binding; protein binding; retinoic acid binding; retinoic acid receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; zinc ion binding

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