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Recombinant Human RBX1

Cat.No. : RBX1-31333TH
Product Overview : Recombinant full lengthhuman ROC1 protein, 12 kDa.
  • Specification
  • Gene Information
  • Related Products
Description : This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
Source : E. coli
Tissue specificity : Widely expressed.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the RING-box family.Contains 1 RING-type zinc finger.
Gene Name : RBX1 ring-box 1, E3 ubiquitin protein ligase [ Homo sapiens ]
Official Symbol : RBX1
Synonyms : RBX1; ring-box 1, E3 ubiquitin protein ligase; ring box 1; E3 ubiquitin-protein ligase RBX1; BA554C12.1; regulator of cullins 1; RNF75; ROC1;
Gene ID : 9978
mRNA Refseq : NM_014248
Protein Refseq : NP_055063
MIM : 603814
Uniprot ID : P62877
Chromosome Location : 22q13.2
Pathway : Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem;
Function : NEDD8 ligase activity; ligase activity; metal ion binding; protein binding; contributes_to ubiquitin-protein ligase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does RBX1 contribute to proteasome-mediated degradation? 12/28/2022

It facilitates the attachment of ubiquitin, directing proteins to the proteasome for breakdown.

What potential therapeutic applications arise from targeting RBX1 in diseases? 07/26/2022

Targeting RBX1 offers potential for treating diseases with dysregulated protein turnover, including cancer.

What is the impact of altered RBX1 activity on cancer development? 02/25/2022

Altered RBX1 activity is associated with cancer progression, influencing cell proliferation and survival.

What role does RBX1 play in cell cycle regulation? 12/22/2020

RBX1 plays a role in cell cycle control by regulating the degradation of key cycle-related proteins.

How do genetic variations in RBX1 affect cellular processes? 11/18/2019

Genetic mutations in RBX1 can lead to disruptions in protein turnover, affecting various cellular functions.

What is the primary role of RBX1 in protein ubiquitination? 05/13/2018

RBX1, a RING-finger protein, is crucial for tagging proteins with ubiquitin, marking them for degradation.

How does RBX1 interact with other components of the ubiquitin-proteasome system? 10/08/2017

RBX1 works with other ubiquitin-proteasome system components, orchestrating protein degradation.

Customer Reviews (3)

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Reviews
03/01/2020

    Efficiency and precision, vital for research quality.

    11/02/2019

      Critical for decision-making, accelerates research productivity.

      04/04/2017

        Enhances research credibility, a cornerstone of our research.

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