"RDH12" Related Products

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Recombinant Human RDH12, His-tagged

Cat.No.: RDH12-31307TH
Product Overview: Recombinant fragment of Human RDH12 (amino acids 39-316) fused to His tag at N-terminus; 303aa, 33.5kDa.
Description: The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).
Protein length: 278 amino acids
Conjugation: HIS
Molecular Weight: 33.500kDa inclusive of tags
Source: E. coli
Tissue specificity: Widely expressed, mostly in eye, kidney, brain, skeletal msucle and stomach.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 1.17% Sodium chloride, 0.03% DTT, 40% Glycerol
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSHMSIRAFAEGFL AEEKQLHILI NNAGVMMCPY SKTADGFETH LGVNHLGHFL LTYLLLERLK VSAPARVVNV SSVAHHIGKI PFHDLQSEKR YSRGFAYCHS KLANVLFTRE LAKRLQGTGV TTYAVHPGVV RSELVRHSSL LCLLWRLFSP FVKTAREGAQ TSLHCALAEG LEPLSGKYFS GKVVV ITGANTGIGK ETARELASRG ARVYIACRDV LKGESAASEI RVDTKNSQVL VRKLDLSDTKDCKRTWVSPR ARNNKTAERL WNVSCELLGI RWE
Sequence Similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Gene Name: RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) [ Homo sapiens ]
Official Symbol: RDH12
Synonyms: RDH12; retinol dehydrogenase 12 (all-trans/9-cis/11-cis); retinol dehydrogenase 12 (all trans and 9 cis); retinol dehydrogenase 12; FLJ30273; LCA13; SDR7C2; short chain dehydrogenase/reductase family 7C; member 2;
Gene ID: 145226
mRNA Refseq: NM_152443
Protein Refseq: NP_689656
MIM: 608830
Uniprot ID: Q96NR8
Chromosome Location: 14q24.1
Pathway: Metabolic pathways, organism-specific biosystem; Retinol metabolism, organism-specific biosystem; Retinol metabolism, conserved biosystem; Visual signal transduction: Cones, organism-specific biosystem; Visual signal transduction: Rods, organism-specific biosystem;
Function: nucleotide binding; oxidoreductase activity; retinol dehydrogenase activity;

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