Recombinant Human RDH12, His-tagged
Cat.No. : | RDH12-31307TH |
Product Overview : | Recombinant fragment of Human RDH12 (amino acids 39-316) fused to His tag at N-terminus; 303aa, 33.5kDa. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3). |
Protein length : | 278 amino acids |
Conjugation : | HIS |
Molecular Weight : | 33.500kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | Widely expressed, mostly in eye, kidney, brain, skeletal msucle and stomach. |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | pH: 8.00Constituents:0.32% Tris HCl, 1.17% Sodium chloride, 0.03% DTT, 40% Glycerol |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MGSHMSIRAFAEGFL AEEKQLHILI NNAGVMMCPY SKTADGFETH LGVNHLGHFL LTYLLLERLK VSAPARVVNV SSVAHHIGKI PFHDLQSEKR YSRGFAYCHS KLANVLFTRE LAKRLQGTGV TTYAVHPGVV RSELVRHSSL LCLLWRLFSP FVKTAREGAQ TSLHCALAEG LEPLSGKYFS GKVVV ITGANTGIGK ETARELASRG ARVYIACRDV LKGESAASEI RVDTKNSQVL VRKLDLSDTKDCKRTWVSPR ARNNKTAERL WNVSCELLGI RWE |
Sequence Similarities : | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Gene Name : | RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) [ Homo sapiens ] |
Official Symbol : | RDH12 |
Synonyms : | RDH12; retinol dehydrogenase 12 (all-trans/9-cis/11-cis); retinol dehydrogenase 12 (all trans and 9 cis); retinol dehydrogenase 12; FLJ30273; LCA13; SDR7C2; short chain dehydrogenase/reductase family 7C; member 2; |
Gene ID : | 145226 |
mRNA Refseq : | NM_152443 |
Protein Refseq : | NP_689656 |
MIM : | 608830 |
Uniprot ID : | Q96NR8 |
Chromosome Location : | 14q24.1 |
Pathway : | Metabolic pathways, organism-specific biosystem; Retinol metabolism, organism-specific biosystem; Retinol metabolism, conserved biosystem; Visual signal transduction: Cones, organism-specific biosystem; Visual signal transduction: Rods, organism-specific biosystem; |
Function : | nucleotide binding; oxidoreductase activity; retinol dehydrogenase activity; |
Products Types
◆ Recombinant Protein | ||
RDH12-7508M | Recombinant Mouse RDH12 Protein, His (Fc)-Avi-tagged | +Inquiry |
RDH12-3655R | Recombinant Rhesus Macaque RDH12 Protein, His (Fc)-Avi-tagged | +Inquiry |
RDH12-2237H | Recombinant Human RDH12, GST-tagged | +Inquiry |
RDH12-4692H | Recombinant Human RDH12 protein, His-SUMO-tagged | +Inquiry |
RDH12-474Z | Recombinant Zebrafish RDH12 | +Inquiry |
◆ Lysates | ||
RDH12-2437HCL | Recombinant Human RDH12 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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