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Recombinant Human REN protein, His-tagged

Cat.No.: REN-30705TH
Product Overview: Recombinant Human REN fused with His tag at C-terminal was expressed in HEK293.
Description: Recombinantly produced in HEK cell culture and purified by chelated metal affinity chromatography. Contains a 8X-Histidine tag at C terminus for purification. Molecular Innovations human renin is produced from the proenzyme prorenin by proteolytic cleavage of a 43 amino acid N-terminal prosegment using limited enzymatic digestion by immobilized trypsin. Conversion to active renin is >99 percent. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N-terminus. This so called prosegment appears to block the full enzymatic potential of the active site. Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects.
Source: HEK293
Species: Human
Tag : His
Form: 0.05M Tris-HCl; 0.05M NaCl; pH 8.0
Molecular Mass: 40000
Purity: >95% by SDS-PAGE analysis
Storage: Store product at –70 centigrade.
Gene Name: REN renin [ Homo sapiens ]
Official Symbol: REN
Synonyms: REN; renin; angiotensinogenase; renin precursor, renal; angiotensin-forming enzyme; HNFJ2; FLJ10761;
Gene ID: 5972
mRNA Refseq: NM_000537
Protein Refseq: NP_000528
MIM: 179820
UniProt ID: P00797

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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