Recombinant Human RGS1, His-tagged
Cat.No. : | RGS1-30015TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 14-209 of Human RGS1 with N-terminal His tag; MWt 26 kDa. |
- Specification
- Gene Information
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Description : | This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. |
Conjugation : | HIS |
Source : | E. coli |
Tissue specificity : | B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high. |
Form : | Liquid |
Storage buffer : | Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Contains 1 RGS domain. |
Gene Name : | RGS1 regulator of G-protein signaling 1 [ Homo sapiens ] |
Official Symbol : | RGS1 |
Synonyms : | RGS1; regulator of G-protein signaling 1; IER1, regulator of G protein signalling 1; 1R20; BL34; IR20; |
Gene ID : | 5996 |
mRNA Refseq : | NM_002922 |
Protein Refseq : | NP_002913 |
MIM : | 600323 |
Uniprot ID : | Q08116 |
Chromosome Location : | 1q31 |
Pathway : | CXCR4-mediated signaling events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; |
Function : | GTPase activator activity; calmodulin binding; signal transducer activity; |
Products Types
◆ Recombinant Protein | ||
RGS1-3689R | Recombinant Rhesus Macaque RGS1 Protein, His (Fc)-Avi-tagged | +Inquiry |
RGS1-7563M | Recombinant Mouse RGS1 Protein, His (Fc)-Avi-tagged | +Inquiry |
RGS1-4672R | Recombinant Rat RGS1 Protein, His (Fc)-Avi-tagged | +Inquiry |
RGS1-6795H | Recombinant Human Regulator of G-protein Signaling 1, His-tagged | +Inquiry |
RGS1-5013R | Recombinant Rat RGS1 Protein | +Inquiry |
◆ Lysates | ||
RGS1-1499HCL | Recombinant Human RGS1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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