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Recombinant Human RGS1, His-tagged

Cat.No. : RGS1-30015TH
Product Overview : Recombinant fragment, corresponding to amino acids 14-209 of Human RGS1 with N-terminal His tag; MWt 26 kDa.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
Conjugation : HIS
Source : E. coli
Tissue specificity : B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
Form : Liquid
Storage buffer : Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Contains 1 RGS domain.
Gene Name : RGS1 regulator of G-protein signaling 1 [ Homo sapiens ]
Official Symbol : RGS1
Synonyms : RGS1; regulator of G-protein signaling 1; IER1, regulator of G protein signalling 1; 1R20; BL34; IR20;
Gene ID : 5996
mRNA Refseq : NM_002922
Protein Refseq : NP_002913
MIM : 600323
Uniprot ID : Q08116
Chromosome Location : 1q31
Pathway : CXCR4-mediated signaling events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem;
Function : GTPase activator activity; calmodulin binding; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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