Recombinant Human RGS4

• Cat.No.: RGS4-29969TH
• Product Overview: Recombinant full length human RGS4 protein, 24 kDa.

Specification

• Description: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene.
• Source: E. coli
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 RGS domain.

Gene Information

• Gene Name: RGS4 regulator of G-protein signaling 4 [ Homo sapiens ]
• Official Symbol: RGS4
• Synonyms: RGS4; regulator of G-protein signaling 4; regulator of G protein signalling 4 , schizophrenia disorder 9 , SCZD9
• Gene ID: 5999
• mRNA Refseq: NM_001102445
• Protein Refseq: NP_001095915
• MIM: 602516
• Uniprot ID: P49798
• Chromosome Location: 1q23.3
• Pathway: Calcium Regulation in the Cardiac Cell, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (z) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
• Function: GTPase activator activity; calmodulin binding; signal transducer activity