Recombinant Human RLN2

• Cat.No.: RLN2-30491TH
• Product Overview: Full length human recombinant Relaxin 2.

Specification

• Description: Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.
• Source: E. coli
• Form: Lyophilised:Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
• Purity: >95% by SDS-PAGE
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: A-Chain: QLYSALANKC CHVGCTKRSL ARFCB-Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS

Gene Information

• Gene Name: RLN2 relaxin 2 [ Homo sapiens ]
• Official Symbol: RLN2
• Synonyms: RLN2; relaxin 2; relaxin 2 (H2); prorelaxin H2; bA12D24.1.1; bA12D24.1.2; H2; relaxin H2; relaxin; ovarian; of pregnancy; RLXH2
• Gene ID: 6019
• mRNA Refseq: NM_005059
• Protein Refseq: NP_005050
• MIM: 179740
• Uniprot ID: P04090
• Chromosome Location: 9pter-q12
• Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem
• Function: hormone activity