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Recombinant Human RPA2, His-tagged

Cat.No. : RPA2-31146TH
Product Overview : Recombinant full-length Human RPA32/RPA2 with a Nterminal His tag; total protein length 293aa inclusive of tag; predicted molecular weight 31.7 kDa.
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Description : Replication Protein A (RPA) is a single stranded DNA binding protein. Human RPA is a heterotrimeric protein containing subunits of 14, 32 and 70kDa.
Protein length : 270 amino acids
Conjugation : HIS
Molecular Weight : 31.700kDa inclusive of tags
Source : E. coli
Form : Liquid
Purity : by SDS-PAGE
Storage buffer : Preservative: 0% NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMGSMW NSGFESYGSSSYGGAGGYTQSPGGF GSPAPSQAEKKSRARAQHIVPCTIS QLLSATLVDEVFRIGNVEISQVTIV GIIRHAEKAPTNIVYKIDDMTAAPM DVRQWVDTDDTSSENTVVPPETYVK VAGHLRSFQNKKSLVAFKIMPLEDM NEFTTHILEVINAHMVLSKANSQPS AGRAPISNPGMSEAGNFGGNSFMPA NGLTVAQNQVLNLIKACPRPEGLNF QDLKNQLKHMSVSSIKQAVDFLSNE GHIYSTVDDDHFKSTDAE
Gene Name : RPA2 replication protein A2, 32kDa [ Homo sapiens ]
Official Symbol : RPA2
Synonyms : RPA2; replication protein A2, 32kDa; replication protein A2 (32kD); replication protein A 32 kDa subunit;
Gene ID : 6118
mRNA Refseq : NM_002946
Protein Refseq : NP_002937
MIM : 179836
Uniprot ID : P15927
Chromosome Location : 1p35
Pathway : Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; Assembly of the RAD51-ssDNA nucleoprotein complex, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem;
Function : DNA binding; nucleic acid binding; protein N-terminus binding; protein binding; protein phosphatase binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How might RPA2 be targeted for cancer therapy? 11/12/2022

Targeting RPA2 with specific inhibitors could disrupt DNA repair mechanisms in cancer cells, rendering them more susceptible to treatments like chemotherapy or radiation therapy.

How does RPA2 contribute to the maintenance of telomeres? 05/09/2019

RPA2 participates in the protection and maintenance of telomeres, the protective caps at the end of chromosomes, thereby contributing to cellular longevity and genomic stability.

Are there any known side effects or challenges associated with targeting RPA2 in therapy? 06/16/2018

Targeting RPA2 in therapy may pose challenges, as its essential role in normal cellular processes raises concerns about potential side effects. Careful modulation is crucial.

Can RPA2 be targeted for therapeutic purposes beyond cancer treatment? 08/01/2017

Yes, exploring RPA2 as a therapeutic target extends to conditions where genomic stability is compromised, such as certain genetic disorders and autoimmune diseases.

Are there any ongoing clinical trials involving RPA2 in cancer treatment? 02/13/2016

Information about specific clinical trials should be checked, but the potential use of RPA2 as a target for cancer therapy is an area of active research.

Customer Reviews (3)

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Reviews
12/21/2020

    This commitment ensures that I have access to the most advanced and reliable protein available, enhancing the integrity and impact of my experiments.

    03/30/2020

      The RPA2 protein exhibits exceptional quality, making it an ideal choice to meet my experimental requirements.

      07/19/2018

        the manufacturer's customer-centric approach highlights their focus on ensuring my satisfaction.

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