Recombinant Human RPA2, His-tagged
Cat.No. : | RPA2-31146TH |
Product Overview : | Recombinant full-length Human RPA32/RPA2 with a Nterminal His tag; total protein length 293aa inclusive of tag; predicted molecular weight 31.7 kDa. |
- Specification
- Gene Information
- Related Products
Description : | Replication Protein A (RPA) is a single stranded DNA binding protein. Human RPA is a heterotrimeric protein containing subunits of 14, 32 and 70kDa. |
Protein length : | 270 amino acids |
Conjugation : | HIS |
Molecular Weight : | 31.700kDa inclusive of tags |
Source : | E. coli |
Form : | Liquid |
Purity : | by SDS-PAGE |
Storage buffer : | Preservative: 0% NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0 |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMGSMW NSGFESYGSSSYGGAGGYTQSPGGF GSPAPSQAEKKSRARAQHIVPCTIS QLLSATLVDEVFRIGNVEISQVTIV GIIRHAEKAPTNIVYKIDDMTAAPM DVRQWVDTDDTSSENTVVPPETYVK VAGHLRSFQNKKSLVAFKIMPLEDM NEFTTHILEVINAHMVLSKANSQPS AGRAPISNPGMSEAGNFGGNSFMPA NGLTVAQNQVLNLIKACPRPEGLNF QDLKNQLKHMSVSSIKQAVDFLSNE GHIYSTVDDDHFKSTDAE |
Gene Name : | RPA2 replication protein A2, 32kDa [ Homo sapiens ] |
Official Symbol : | RPA2 |
Synonyms : | RPA2; replication protein A2, 32kDa; replication protein A2 (32kD); replication protein A 32 kDa subunit; |
Gene ID : | 6118 |
mRNA Refseq : | NM_002946 |
Protein Refseq : | NP_002937 |
MIM : | 179836 |
Uniprot ID : | P15927 |
Chromosome Location : | 1p35 |
Pathway : | Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; Assembly of the RAD51-ssDNA nucleoprotein complex, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; |
Function : | DNA binding; nucleic acid binding; protein N-terminus binding; protein binding; protein phosphatase binding; |
Products Types
◆ Recombinant Protein | ||
RPA2-4758R | Recombinant Rat RPA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
RPA2-3776R | Recombinant Rhesus Macaque RPA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Rpa2-5579M | Recombinant Mouse Rpa2 Protein, Myc/DDK-tagged | +Inquiry |
RPA2-1910H | Recombinant Human RPA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
RPA2-3440H | Recombinant Human RPA2 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
RPA2-2242HCL | Recombinant Human RPA2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTargeting RPA2 with specific inhibitors could disrupt DNA repair mechanisms in cancer cells, rendering them more susceptible to treatments like chemotherapy or radiation therapy.
RPA2 participates in the protection and maintenance of telomeres, the protective caps at the end of chromosomes, thereby contributing to cellular longevity and genomic stability.
Targeting RPA2 in therapy may pose challenges, as its essential role in normal cellular processes raises concerns about potential side effects. Careful modulation is crucial.
Yes, exploring RPA2 as a therapeutic target extends to conditions where genomic stability is compromised, such as certain genetic disorders and autoimmune diseases.
Information about specific clinical trials should be checked, but the potential use of RPA2 as a target for cancer therapy is an area of active research.
Customer Reviews (3)
Write a reviewThis commitment ensures that I have access to the most advanced and reliable protein available, enhancing the integrity and impact of my experiments.
The RPA2 protein exhibits exceptional quality, making it an ideal choice to meet my experimental requirements.
the manufacturer's customer-centric approach highlights their focus on ensuring my satisfaction.
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