Recombinant Human RPS6KA3

• Cat.No.: RPS6KA3-30417TH
• Product Overview: Recombinant full length Rsk 2 / MAPKAP Kinase 1b protein (Human), was expressed by baculovirus in Sf9 insect cells using a N-terminal tag, MW 112 kDa.

Specification

• Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
• Tissue specificity: Expressed in many tissues, highest levels in skeletal muscle.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 2 protein kinase domains.

Gene Information

• Gene Name: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [ Homo sapiens ]
• Official Symbol: RPS6KA3
• Synonyms: RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; CLS, Coffin Lowry syndrome , mental retardation, X linked 19 , MRX19, ribosomal protein S6 kinase, 90kD, polypeptide 3; ribosomal protein S6 kinase alpha-3; HU 3; RSK; RSK2
• Gene ID: 6197
• mRNA Refseq: NM_004586
• Protein Refseq: NP_004577
• MIM: 300075
• Uniprot ID: P51812
• Chromosome Location: Xp22.2-p22.1
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Axon guidance, organism-specific biosystem; CREB phosphorylation, organism-specific biosystem; CREB phosphorylation through the activation of Ras, organism-specific biosystem
• Function: ATP binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; magnesium ion binding; nucleotide binding; protein kinase activity