Recombinant Human RPS6KA4, His-tagged

• Cat.No.: RPS6KA4-29913TH
• Product Overview: Recombinant fragment, corresponding to amino acids 269-572 of Human MSK2 / RSK-B isoform 2 with a N terminal His tag; Pred MWt 34kDa:

Specification

• Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:reconstitution with 166 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: AQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVA LAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPG SPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGA GDRPGRAAVARSAMMQQYELDLREPALGQGSFSVCRRCRQ RQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVN LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEA SQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG APVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAP

Gene Information

• Gene Name: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 [ Homo sapiens ]
• Official Symbol: RPS6KA4
• Synonyms: RPS6KA4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; ribosomal protein S6 kinase, 90kD, polypeptide 4; ribosomal protein S6 kinase alpha-4; MSK2; RSK B
• Gene ID: 8986
• mRNA Refseq: NM_001006944
• Protein Refseq: NP_001006945
• MIM: 603606
• Uniprot ID: O75676
• Chromosome Location: 11q11-q13
• Pathway: Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; L1CAM interactions, organism-specific biosystem
• Function: ATP binding; magnesium ion binding; mitogen-activated protein kinase p38 binding; nucleotide binding; protein binding