Recombinant Human RUVBL2, His-tagged

• Cat.No.: RUVBL2-30950TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-463 of Human Reptin/TIP49B/RUVB2 with a N terminal His tag; MWt 58

Specification

• Description: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Ubiquitously expressed. Highly expressed in testis and thymus.
• Form: Lyophilised:Reconstitution with 139 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MATVTATTKVPEIRDVTRIERIGAH SHIRGLGLDDALEPR QASQGMVGQLAARRAAGVVLEMIRE GKIAGRAVLIAGQ PGTGKTAIAMGMAQALGPDTPFTAI AGSEIFSLEMSKT EALTQAFRRSIGVRIKEETEIIEGE VVEIQIDRPATGTGS KVGKLTLKTTEMETIYDLGTKMIES LTKDKVQAGDVIT IDKATGKISKLGRSFTRARDYDAMG SQTKFVQCPDGEL QKRKEVVHTVSLHEIDVINSRTQGF LALFSGDTGEIKS EVREQINAKVAEWREEGKAEIIPGV LFIDEVHMLDIESFS FLNRALESDMAPVLIMATNRGITRI RGTSYQSPHGIPI DLLDRLLIVSTTPYSEKDTKQILRI RCEEEDVEMSEDA YTVLTRIGLETSLRYAIQLITAASL VCRKRKGTEVQVDDIKRVYSLFLDE SRSTQYMKEYQDAFLFNELKGETMD TS
• Sequence Similarities: Belongs to the ruvB family.
• Publication:
  Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies to self-antigens (2023)

Gene Information

• Gene Name: RUVBL2 RuvB-like 2 (E. coli) [ Homo sapiens ]
• Official Symbol: RUVBL2
• Synonyms: RUVBL2; RuvB-like 2 (E. coli); RuvB (E coli homolog) like 2; ruvB-like 2; ECP51; INO80 complex subunit J; INO80J; reptin; Reptin52; Rvb2; RVB2; TIH2; TIP48; TIP49b
• Gene ID: 10856
• mRNA Refseq: NM_006666
• Protein Refseq: NP_006657
• MIM: 604788
• Uniprot ID: Q9Y230
• Chromosome Location: 19q13.3
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; C-MYC pathway, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; Extension of Telomeres, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
• Function: ATP binding; ATP-dependent DNA helicase activity; contributes_to ATPase activity; DNA helicase activity; damaged DNA binding