| Description : |
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
| Protein length : |
369 amino acids |
| Conjugation : |
HIS |
| Molecular Weight : |
45.200kDa inclusive of tags |
| Source : |
E. coli |
| Tissue specificity : |
Expressed at high levels in the CNS, as well as in heart and platelets (at protein level). |
| Form : |
Liquid |
| Purity : |
>90% by SDS-PAGE |
| Storage buffer : |
Preservative: NoneConstituents: 40% Glycerol, 0.3M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0 |
| Storage : |
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| Sequences of amino acids : |
MGSSHHHHHHSSGLVPRGSHMGSMS TGLRYKSKLATPEDKQDIDKQYVGF ATLPNQVHRKSVKKGFDFTLMVAGE SGLGKSTLVHSLFLTDLYKDRKLLS AEERISQTVEILKHTVDIEEKGVKL KLTIVDTPGFGDAVNNTECWKPITD YVDQQFEQYFRDESGLNRKNIQDNR VHCCLYFISPFGHGLRPVDVGFMKA LHEKVNIVPLIAKADCLVPSEIRKL KERIREEIDKFGIHVYQFPECDSDE DEDFKQQDRELKESAPFAVIGSNTV VEAKGQRVRGRLYPWGIVEVENQAH CDFVKLRNMLIRTHMHDLKDVTCDV HYENYRAHCIQQMTSKLTQDSRMES PIPILPLPTPDAETEKLIRMKDEEL RRMQEMLQRMKQQMQDQ |
| Sequence Similarities : |
Belongs to the septin family. |
