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Recombinant Mouse Left Right Determination Factor 1

Cat. No.: Lefty1-1765M
Description: Lefty proteins are signaling ligands that act in opposition to the NODAL protein. During vertebrate development they regulate the degree of left-right asymmetry by controlling the spatiotemporal influence of the NODAL protein. The role of Lefty1 is to restrict the expression of Lefty2 and Nodal to the left side, and that Lefty2 or Nodal encode a signal for "leftness." Lefty2 serves as a feedback inhibitor to restrict the range of nodal signaling during establishment of the left-right axis.
Molecular Weight: By N-terminal sequencing, two peptides corresponding to mouse Lefty-1 propeptide (with Leu 22 at the amino-terminus) and mature Lefty-1 (with a histidine residue at the amino-terminus) are present in the recombinant preparation. In SDS-PAGE under reducing conditions, the propeptide and mature Lefty-1 have apparent molecular masses of 12 kDa and 36 kDa, respectively. The two peptides apparently remained associated after processing and during protein purification.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >90% by SDS Page and analyzed by silver stain.
Endotoxin: <0.1 ng per 1 µg as determined by the LAL method
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Lefty1 left right determination factor 1 [ Mus musculus ]
Synonyms: Lefty1; left right determination factor 1; Ebaf; Leftb; Stra3; Tgfb4; lefty; lefty-1; AI450052; OTTMUSP00000023876; left-right determination, factor B
Gene ID: 13590
mRNA Refseq: NM_010094
Protein Refseq: NP_034224
UniProt ID: Q64280
Chromosome Location: 1F
Pathway: TGF-beta signaling pathway
Function: cytokine activity; growth factor activity; transforming growth factor beta receptor binding

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