Recombinant Human SETD2
Cat.No. : | SETD2-27850TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 915-1211of Human KMT3A / HYPB / HIF-1, with N-terminal proprietary tag, 59.7 kDa. |
- Specification
- Gene Information
- Related Products
Description : | Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. |
Source : | E. coli |
Biological activity : | Specific activity assay conditions: Assay conditions: 80 μlreaction mix (50 mM TRIS pH8.8, 5 mM MgCl2, 4 mM DTT, 20 μM substrate (histone H3), 12.5 μM S-adenosylhomocysteine, and 0-2.5 μM Set2) incubate for 1 hr at 37oC. Add fluorescently labeled tracer a |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Gene Name : | SETD2 SET domain containing 2 [ Homo sapiens ] |
Official Symbol : | SETD2 |
Synonyms : | SETD2; SET domain containing 2; histone-lysine N-methyltransferase SETD2; FLJ23184; HIF 1; HYPB; KIAA1732; KMT3A; |
Gene ID : | 29072 |
mRNA Refseq : | NM_014159 |
Protein Refseq : | NP_054878 |
MIM : | 612778 |
Uniprot ID : | Q9BYW2 |
Chromosome Location : | 3p21.31 |
Pathway : | Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; |
Function : | DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; oxidoreductase activity; transferase activity; |
Products Types
◆ Recombinant Protein | ||
SETD2-116H | Recombinant Human SETD2 Protein, His-tagged | +Inquiry |
SETD2-8067M | Recombinant Mouse SETD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
SETD2-023H | Recombinant Human SETD2 Protein, His-tagged | +Inquiry |
SETD2-460H | Recombinant Human SET Domain Containing 2, GST-tagged | +Inquiry |
SETD2-260H | Recombinant Human SETD2 protein, GST-tagged | +Inquiry |
◆ Assay kits | ||
Kit-1864 | SETD2 Chemiluminescent Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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