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Recombinant Human SIRT2, His-tagged

Cat.No.: SIRT2-30566TH
Product Overview: Recombinant full length Human SIRT2 with N terminal His tag; MWt 42 kDa.
Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
Protein length: 351 amino acids
Conjugation: HIS
Molecular Weight: 42.000kDa inclusive of tags
Source: Baculovirus
Tissue specificity: Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulatio
Biological activity: Specific Activity: 8000 RLU/min/ng.
Form: Liquid
Purity: Densitometry
Storage buffer: Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.0
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.
Gene Name: SIRT2 sirtuin 2 [ Homo sapiens ]
Official Symbol: SIRT2
Synonyms: SIRT2; sirtuin 2; SIR2L, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; NAD-dependent deacetylase sirtuin-2;
Gene ID: 22933
mRNA Refseq: NM_001193286
Protein Refseq: NP_001180215
MIM: 604480
Uniprot ID: Q8IXJ6
Chromosome Location: 19q13
Pathway: Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem;
Function: NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding;

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