"SLC18A1" Related Products

Recombinant Human SLC18A1

Cat.No.: SLC18A1-29829TH
Product Overview: Recombinant full length Human VMAT1 with N terminal proprietary tag; Predicted MWt 80.34 kDa.
Description: The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al.
Protein length: 494 amino acids
Molecular Weight: 80.340kDa inclusive of tags
Source: Wheat germ
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: MLRPILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTV VVPIVPTFLYDMEFKEVNSSLHLGHAGSSPHALASPAFST IFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISA HKNNCLQGTGFLEEETTRVGVLFASKAVMQLLVNPFVGPL TNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQ GIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGL LVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQP SKVSPESAKGTPLFMLLKDPYILVAAGLAFLPASVSYLIG TNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGL IGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAI ADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYA PLCYYLRSPPAKEEKLAILSQDCPMETRMYATQKPTKEFP LGEDSDEEPDHEE
Sequence Similarities: Belongs to the major facilitator superfamily. Vesicular transporter family.
Gene Name: SLC18A1 solute carrier family 18 (vesicular monoamine), member 1 [ Homo sapiens ]
Official Symbol: SLC18A1
Synonyms: SLC18A1; solute carrier family 18 (vesicular monoamine), member 1; VAT1, VMAT1; chromaffin granule amine transporter; CGAT;
Gene ID: 6570
mRNA Refseq: NM_001135691
Protein Refseq: NP_001129163
MIM: 193002
Uniprot ID: P54219
Chromosome Location: 8p21.3
Pathway: Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; Na+/Cl- dependent neurotransmitter transporters, organism-specific biosystem; Parkinsons disease, organism-specific biosystem; SLC-mediated transmembrane transport, organism-specific biosystem;
Function: drug transmembrane transporter activity; enzyme binding; monoamine transmembrane transporter activity; serotonin transmembrane transporter activity;

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