Recombinant Human SLC18A1

• Cat.No.: SLC18A1-29829TH
• Product Overview: Recombinant full length Human VMAT1 with N terminal proprietary tag; Predicted MWt 80.34 kDa.

Specification

• Description: The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al.
• Protein length: 494 amino acids
• Molecular Weight: 80.340kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MLRPILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTV VVPIVPTFLYDMEFKEVNSSLHLGHAGSSPHALASPAFST IFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISA HKNNCLQGTGFLEEETTRVGVLFASKAVMQLLVNPFVGPL TNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQ GIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGL LVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQP SKVSPESAKGTPLFMLLKDPYILVAAGLAFLPASVSYLIG TNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGL IGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAI ADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYA PLCYYLRSPPAKEEKLAILSQDCPMETRMYATQKPTKEFP LGEDSDEEPDHEE
• Sequence Similarities: Belongs to the major facilitator superfamily. Vesicular transporter family.

Gene Information

• Gene Name: SLC18A1 solute carrier family 18 (vesicular monoamine), member 1 [ Homo sapiens ]
• Official Symbol: SLC18A1
• Synonyms: SLC18A1; solute carrier family 18 (vesicular monoamine), member 1; VAT1, VMAT1; chromaffin granule amine transporter; CGAT
• Gene ID: 6570
• mRNA Refseq: NM_001135691
• Protein Refseq: NP_001129163
• MIM: 193002
• Uniprot ID: P54219
• Chromosome Location: 8p21.3
• Pathway: Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; Na+/Cl- dependent neurotransmitter transporters, organism-specific biosystem; Parkinsons disease, organism-specific biosystem; SLC-mediated transmembrane transport, organism-specific biosystem
• Function: drug transmembrane transporter activity; enzyme binding; monoamine transmembrane transporter activity; serotonin transmembrane transporter activity