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Recombinant Human SMC3, His-tagged

Cat.No. : SMC3-31196TH
Product Overview : Recombinant fragment, corresponding to amino acids 233-736 of Human SMC3 with a N terminal His tag; predicted MWt 60 kDa:
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  • Gene Information
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Description : This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
Conjugation : HIS
Source : E. coli
Form : Lyophilised:Reconstitution with 118 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : NETRAKLDELSAKRETSGEKSRQLR DAQQDARDKMEDIER QVRELKTKISAMKEEKEQLSAERQE QIKQRTKLELKAK DLQDELAGNSEQRKRLLKERQKLLE KIEEKQKELAETE PKFNSVKEKEERGIARLAQATQERT DLYAKQGRGSQFTSK EERDKWIKKELKSLDQAINDKKRQI AAIHKDLEDTEAN KEKNLEQYNKLDQDLNEVKARVEEL DRKYYEVKNKKDE LQSERNYLWREENAEQQALAAKRED LEKKQQLLRAATG KAILNGIDSINKVLDHFRRKGINQH VQNGYHGIVMNNFEC EPAFYTCVEVTAGNRLFYHIVDSDE VSTKILMEFNKMN LPGEVTFLPLNKLDVRDTAYPETND AIPMISKLRYNPR FDKAFKHVFGKTLICRSMEVSTQLA RAFTMDCITLEGDQVSHRGALTGGY YDTRKSRLELQKDVRKAEEELGELE AKL NENLRRNIERINNEIDQLMNQMQQI ETQQRKFKASRDS IL
Sequence Similarities : Belongs to the SMC family. SMC3 subfamily.
Gene Name : SMC3 structural maintenance of chromosomes 3 [ Homo sapiens ]
Official Symbol : SMC3
Synonyms : SMC3; structural maintenance of chromosomes 3; chondroitin sulfate proteoglycan 6 (bamacan) , CSPG6; structural maintenance of chromosomes protein 3; BAM; bamacan; bamacan proteoglycan; HCAP; SMC3L1;
Gene ID : 9126
mRNA Refseq : NM_005445
Protein Refseq : NP_005436
MIM : 606062
Uniprot ID : Q9UQE7
Chromosome Location : 10q25
Pathway : Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; DNA Replication, organism-specific biosystem; M Phase, organism-specific biosystem;
Function : ATP binding; dynein binding; microtubule motor activity; nucleotide binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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