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Recombinant Human SMO

Cat.No. : SMO-31421TH
Product Overview : Recombinant fragment corresponding to amino acids 56-155 of Human Smoothened with proprietary tag; Predicted MWt 36.63 kDa.
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  • Gene Information
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Description : The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : GPPPPLSHCGRAAPCEPLRYNVCLG SVLPYGATSTLLAGDSDSQEEAHGK LVLWSGLRNAPRCWAVIQPLLCAVY MPKCENDRVELPSRTLCQATRGPCA
Sequence Similarities : Belongs to the G-protein coupled receptor Fz/Smo family.Contains 1 FZ (frizzled) domain.
Gene Name : SMO smoothened, frizzled family receptor [ Homo sapiens ]
Official Symbol : SMO
Synonyms : SMO; smoothened, frizzled family receptor; SMOH, smoothened (Drosophila) homolog , smoothened homolog (Drosophila) , smoothened, seven transmembrane spanning receptor; smoothened homolog; frizzled family member 11; FZD11;
Gene ID : 6608
mRNA Refseq : NM_005631
Protein Refseq : NP_005622
MIM : 601500
Uniprot ID : Q99835
Chromosome Location : 7q32.1
Pathway : Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Other, organism-specific biosystem;
Function : G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; drug binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does the dysregulation of SMO protein contribute to cancer development? 07/30/2021

Aberrant activation of the SMO protein is associated with several types of cancer, including basal cell carcinoma and medulloblastoma. Mutations or overexpression of SMO can lead to uncontrolled cell growth and tumorigenesis.

Are there ongoing research efforts to discover new clinical applications for SMO protein modulation? 12/29/2020

Yes, researchers are actively investigating the role of SMO protein in various diseases beyond cancer, including neurological disorders and regenerative medicine.

How does SMO protein modulation impact stem cell behavior and differentiation? 12/04/2020

SMO protein modulation can influence stem cell fate decisions, playing a role in processes such as self-renewal and differentiation.

What are the current clinical applications of SMO inhibitors in cancer treatment? 09/20/2018

SMO inhibitors are being explored as therapeutic agents in cancer treatment, particularly for tumors driven by abnormal Hedgehog signaling. These inhibitors aim to block the activity of SMO and, consequently, disrupt the downstream signaling cascade.

In which cancer types have SMO inhibitors shown promising results in clinical trials? 05/11/2018

Clinical trials have shown promise for SMO inhibitors in treating basal cell carcinoma, medulloblastoma, and other cancers with dysregulated Hedgehog signaling.

Customer Reviews (3)

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Reviews
11/23/2021

    The manufacturer of SMO protein plays a crucial role in supporting my research endeavors.

    11/16/2018

      The use of SMO protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.

      08/22/2018

        Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.

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