Recombinant Human SMO
Cat.No. : | SMO-31421TH |
Product Overview : | Recombinant fragment corresponding to amino acids 56-155 of Human Smoothened with proprietary tag; Predicted MWt 36.63 kDa. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. |
Protein length : | 100 amino acids |
Molecular Weight : | 36.630kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | GPPPPLSHCGRAAPCEPLRYNVCLG SVLPYGATSTLLAGDSDSQEEAHGK LVLWSGLRNAPRCWAVIQPLLCAVY MPKCENDRVELPSRTLCQATRGPCA |
Sequence Similarities : | Belongs to the G-protein coupled receptor Fz/Smo family.Contains 1 FZ (frizzled) domain. |
Gene Name : | SMO smoothened, frizzled family receptor [ Homo sapiens ] |
Official Symbol : | SMO |
Synonyms : | SMO; smoothened, frizzled family receptor; SMOH, smoothened (Drosophila) homolog , smoothened homolog (Drosophila) , smoothened, seven transmembrane spanning receptor; smoothened homolog; frizzled family member 11; FZD11; |
Gene ID : | 6608 |
mRNA Refseq : | NM_005631 |
Protein Refseq : | NP_005622 |
MIM : | 601500 |
Uniprot ID : | Q99835 |
Chromosome Location : | 7q32.1 |
Pathway : | Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; |
Function : | G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; drug binding; |
Products Types
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionAberrant activation of the SMO protein is associated with several types of cancer, including basal cell carcinoma and medulloblastoma. Mutations or overexpression of SMO can lead to uncontrolled cell growth and tumorigenesis.
Yes, researchers are actively investigating the role of SMO protein in various diseases beyond cancer, including neurological disorders and regenerative medicine.
SMO protein modulation can influence stem cell fate decisions, playing a role in processes such as self-renewal and differentiation.
SMO inhibitors are being explored as therapeutic agents in cancer treatment, particularly for tumors driven by abnormal Hedgehog signaling. These inhibitors aim to block the activity of SMO and, consequently, disrupt the downstream signaling cascade.
Clinical trials have shown promise for SMO inhibitors in treating basal cell carcinoma, medulloblastoma, and other cancers with dysregulated Hedgehog signaling.
Customer Reviews (3)
Write a reviewThe manufacturer of SMO protein plays a crucial role in supporting my research endeavors.
The use of SMO protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.
Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.
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