"SNAP25" Related Products

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Recombinant Human SNAP25

Cat.No.: SNAP25-31426TH
Product Overview: Recombinant full length Human SNAP25, isoform B; 206aa, 23 kDa.
Description: Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Source: E. coli
Tissue specificity: Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 25mM Tris, 2mM EDTA, 1mM DTT, pH 7.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids: MAEDADMRNE LEEMQRRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLERI EEGMDQINKD MKEAEKNLTD LGKFCGLCVC PCNKLKSSDA YKKAWGNNQD GVVASQPARV VDEREQMAIS GGFIRRVTND ARENEMDENL EQVSGIIGNL RHMALDMGNE IDTQNRQIDR IMEKADSNKT RIDEANQRAT KMLGSG
Sequence Similarities: Belongs to the SNAP-25 family.Contains 2 t-SNARE coiled-coil homology domains.
Gene Name: SNAP25 synaptosomal-associated protein, 25kDa [ Homo sapiens ]
Official Symbol: SNAP25
Synonyms: SNAP25; synaptosomal-associated protein, 25kDa; SNAP, synaptosomal associated protein, 25kD; synaptosomal-associated protein 25; bA416N4.2; dJ1068F16.2; resistance to inhibitors of cholinesterase 4 homolog; RIC 4; RIC4; SEC9; SNAP 25;
Gene ID: 6616
mRNA Refseq: NM_003081
Protein Refseq: NP_003072
MIM: 600322
Uniprot ID: P60880
Chromosome Location: 20p12-p11.2
Pathway: Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystem; BoNT Light Chain Types A, C1, E cleave SNAP-25, organism-specific biosystem; Botulinum neurotoxicity, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Dopamine Neurotransmitter Release Cycle, organism-specific biosystem;
Function: SNARE binding; myosin binding; protein N-terminus binding; protein binding; protein domain specific binding;

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