||Recombinant full length protein (Human); A Parkinsons disease-related point mutant (A30P).
||Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
||Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
||>95% by SDS-PAGE
||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||MDVFMKGLSK/AKEGVVAAAE/KTKQGVAEA[P]/GKTKE GVLYV/GSKTKEGVVH/GVATVAEKTK/EQVTNVGGAV /VTGVTAVAQK/TVEGAGSIAA/ATGFVKKDQL/ GKNEEGAPQE/GILEDMPVDP/DNEAYEMPSE/EGYQDYE PEA/
||Belongs to the synuclein family.