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Recombinant Human SPP1

Cat.No. : SPP1-30522TH
Product Overview : Recombinant full length Human Osteopontin expressed in 293 cells, 60-65 kDa.
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  • Gene Information
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Description : The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
Tissue specificity : Bone. Found in plasma.
Biological activity : Biological Activity : Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.
Form : Lyophilised
Purity : >95% by SDS-PAGE
Storage : Store at -20°C. Stable for 12 months at -20°C
Sequences of amino acids : IPVKQADSGS SEEKQLYNKY PDAVATWLNP DPSQKQNLLA PQNAVSSEET NDFKQETLPS KSNESHDHMD DMDDEDDDDH VDSQDSIDSN DSDDVDDTDD SHQSDESHHS DESDELVTDF PTDLPATEVF TPVVPTVDTY DGRGDSVVYG LRSKSKKFRR PDIQYPDATD EDITSHMESE ELNGAYKAIP VAQDLNAPSD WDSRGKDSYE TSQLDDQSAE THSHKQSRLY KRKANDESNE HSDVIDSQEL SKVSREFHSH EFHSHEDMLV VDPKSKEEDK HLKFRISHEL DSASSEVN
Sequence Similarities : Belongs to the osteopontin family.
Gene Name : SPP1 secreted phosphoprotein 1 [ Homo sapiens ]
Official Symbol : SPP1
Synonyms : SPP1; secreted phosphoprotein 1; BNSP, bone sialoprotein I , OPN, osteopontin; osteopontin; BSPI; early T lymphocyte activation 1; ETA 1;
Gene ID : 6696
mRNA Refseq : NM_000582
Protein Refseq : NP_000573
MIM : 166490
Uniprot ID : P10451
Chromosome Location : 4q22.1
Pathway : Direct p53 effectors, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem;
Function : cytokine activity; extracellular matrix binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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