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Recombinant Human STAT4, His-tagged

Cat.No. : STAT4-30117TH
Product Overview : Recombinant full length Human STAT4 with N terminal His tag, expressed in a Baculovirus infected Sf9 cell expression system, amino acids 1-748, MW 87kDa.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
Conjugation : HIS
Form : Liquid
Storage buffer : Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 0.1% PMSF, 50mM Sodium phosphate, 300mM Sodium chloride, 0.2mM DTT, pH 7
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the transcription factor STAT family.Contains 1 SH2 domain.
Gene Name : STAT4 signal transducer and activator of transcription 4 [ Homo sapiens ]
Official Symbol : STAT4
Synonyms : STAT4; signal transducer and activator of transcription 4;
Gene ID : 6775
mRNA Refseq : NM_001243835
Protein Refseq : NP_001230764
MIM : 600558
Uniprot ID : Q14765
Chromosome Location : 2q32.2-q32.3
Pathway : Downstream signaling in naive CD8+ T cells, organism-specific biosystem; IL12 signaling mediated by STAT4, organism-specific biosystem; IL12-mediated signaling events, organism-specific biosystem; IL23-mediated signaling events, organism-specific biosystem; IL27-mediated signaling events, organism-specific biosystem;
Function : calcium ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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