"TANK" Related Products

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Recombinant Human TANK

Cat.No.: TANK-31497TH
Product Overview: Recombinant fragment, corresponding to amino acids 1-119 of human TANK isoform b; 119 amino acids, 13.6 kDa.
Description: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source: E. coli
Tissue specificity: Ubiquitous.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 20mM Tris, pH 8.0
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIASAESSI
Sequence Similarities: Contains 1 C2H2-type zinc finger.
Gene Name: TANK TRAF family member-associated NFKB activator [ Homo sapiens ]
Official Symbol: TANK
Synonyms: TANK; TRAF family member-associated NFKB activator; TRAF2; TRAF family member-associated NF-kappa-B activator; I TRAF;
Gene ID: 10010
mRNA Refseq: NM_004180
Protein Refseq: NP_004171
MIM: 603893
Uniprot ID: Q92844
Chromosome Location: 2q24-q31
Pathway: Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; RIG-I-like receptor signaling pathway, organism-specific biosystem; RIG-I-like receptor signaling pathway, conserved biosystem; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem;
Function: metal ion binding; protein binding;

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