Recombinant Human TCL1A

• Cat.No.: TCL1A-30569TH
• Product Overview: Recombinant full length Human Tcl1; amino acids 1-114 , 13.4kDa.

Specification

• Description: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al.
• Source: E. coli
• Tissue specificity: Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 50mM Tris HCl, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD
• Sequence Similarities: Belongs to the TCL1 family.

Gene Information

• Gene Name: TCL1A T-cell leukemia/lymphoma 1A [ Homo sapiens ]
• Official Symbol: TCL1A
• Synonyms: TCL1A; T-cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A; TCL1
• Gene ID: 8115
• mRNA Refseq: NM_001098725
• Protein Refseq: NP_001092195
• MIM: 186960
• Uniprot ID: P56279
• Chromosome Location: 14q32.1
• Function: protein binding