"TEK" Related Products

Expand
Expand
Expand

Recombinant Human TEK, Fc-tagged

Cat.No.: TEK-30629TH
Product Overview: Recombinant fusion protein (Human).Recombinant human soluble TIE 2 was fused with the Fc part of human IgG1.The recombinant mature sTIE 2/Fc is a disulfide-linked homodimeric protein.The soluble receptor protein consists of the full extracellular domain (
Description: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1.Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
Conjugation: Fc
Tissue specificity: Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
Form: Lyophilised:The lyophilised sTIE-2/Fc is soluble in water and most aqueous buffers.The lyophilised sTIE-2/Fc should be reconstituted in PBS or medium to a concentration not lower than 50 μg/ml.
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: PBS
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.Contains 3 EGF-like domains.Contains 3 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.
Gene Name: TEK TEK tyrosine kinase, endothelial [ Homo sapiens ]
Official Symbol: TEK
Synonyms: TEK; TEK tyrosine kinase, endothelial; venous malformations, multiple cutaneous and mucosal , VMCM; angiopoietin-1 receptor; CD202b; TIE 2; TIE2; VMCM1;
Gene ID: 7010
mRNA Refseq: NM_000459
Protein Refseq: NP_000450
MIM: 600221
Uniprot ID: Q02763
Chromosome Location: 9p21
Pathway: Angiogenesis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem;
Function: ATP binding; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.