||Recombinant fusion protein (Human).Recombinant human soluble TIE 2 was fused with the Fc part of human IgG1.The recombinant mature sTIE 2/Fc is a disulfide-linked homodimeric protein.The soluble receptor protein consists of the full extracellular domain (
||The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1.Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
||Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
||Lyophilised:The lyophilised sTIE-2/Fc is soluble in water and most aqueous buffers.The lyophilised sTIE-2/Fc should be reconstituted in PBS or medium to a concentration not lower than 50 μg/ml.
||>90% by SDS-PAGE
||Preservative: NoneConstituents: PBS
||Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
||Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.Contains 3 EGF-like domains.Contains 3 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.