Recombinant Human TEK, His-tagged
Cat.No. : | TEK-31525TH |
Product Overview : | Recombinant fragment of Human TIE2 (amino acids 771-end) with an N terminal His tag. |
- Specification
- Gene Information
- Related Products
Description : | The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1.Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. |
Conjugation : | HIS |
Tissue specificity : | Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney. |
Biological activity : | 140 U/μg. One unit is defined as the amount of enzyme that will phosphorylate 1 pmol of Tyr substrate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 3 mM MgCl2, 3 mM MnCl2, 1 mM DTT, 3 μM Na-orthovanadate, 0.5 mM ATP, 30 μg/ml Poly (Glu |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.Contains 3 EGF-like domains.Contains 3 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain. |
Gene Name : | TEK TEK tyrosine kinase, endothelial [ Homo sapiens ] |
Official Symbol : | TEK |
Synonyms : | TEK; TEK tyrosine kinase, endothelial; venous malformations, multiple cutaneous and mucosal , VMCM; angiopoietin-1 receptor; CD202b; TIE 2; TIE2; VMCM1; |
Gene ID : | 7010 |
mRNA Refseq : | NM_000459 |
Protein Refseq : | NP_000450 |
MIM : | 600221 |
Uniprot ID : | Q02763 |
Chromosome Location : | 9p21 |
Pathway : | Angiogenesis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; |
Function : | ATP binding; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
Tek-148M | Recombinant Mouse Tek Protein, His (Fc)-Avi-tagged | +Inquiry |
TEK-2758H | Recombinant Human TEK Protein, His-tagged | +Inquiry |
TEK-008H | Active Recombinant Human TEK Protein, hIgG/His-tagged | +Inquiry |
TEK-996R | Recombinant Rhesus TEK Protein (Met1-Lys745), His-tagged | +Inquiry |
Tek-7419M | Active Recombinant Mouse Tek protein(Gln770-Ala1122), His&GST-tagged | +Inquiry |
◆ Lysates | ||
TEK-404MCL | Recombinant Mouse TEK cell lysate | +Inquiry |
TEK-1707RCL | Recombinant Rat TEK cell lysate | +Inquiry |
TEK-415HCL | Recombinant Human TEK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionThe TEK gene is crucial for vascular development during embryogenesis, coordinating with other genes and signaling pathways to ensure proper formation of the vascular system.
The TEK gene is implicated in pathological angiogenesis in diseases like cancer, where dysregulation of TIE2 signaling can contribute to aberrant blood vessel formation.
The TEK gene, through TIE2 signaling, regulates vascular permeability by influencing the integrity of endothelial cell junctions and controlling the passage of molecules across blood vessels.
The TEK gene contributes to the maintenance of vascular quiescence by suppressing endothelial cell activation and inflammation, preserving the stability of blood vessels.
The TEK gene, through TIE2 signaling, influences immune responses by modulating interactions between endothelial cells and immune cells during vascular inflammation.
Customer Reviews (3)
Write a reviewOutstanding service! Staff expertise helped us choose the perfect protein.
Seamless delivery process—ordered, received, and ready for experiments.
Courteous and efficient customer service made our purchase hassle-free.
Ask a Question for All TEK Products
Required fields are marked with *
My Review for All TEK Products
Required fields are marked with *
Inquiry Basket