Recombinant Human TGFBR1

• Cat.No.: TGFBR1-31137TH
• Product Overview: Recombinant fragment of Human TGF beta Receptor I with N-terminal proprietary tag, 424 amino acids, MWt 66kDa.

Specification

• Description: The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
• Protein length: 424 amino acids
• Molecular Weight: 66.000kDa inclusive of tags
• Source: Baculovirus infected sf9 cells
• Tissue specificity: Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
• Biological activity: The Specific activity of TGFBR1-31137TH was determined to be 3 nmol/min/mg.
• Form: Liquid
• Purity: Densitometry
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 GS domain.Contains 1 protein kinase domain.

Gene Information

• Gene Name: TGFBR1 transforming growth factor, beta receptor 1 [ Homo sapiens ]
• Official Symbol: TGFBR1
• Synonyms: TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5
• Gene ID: 7046
• mRNA Refseq: NM_001130916
• Protein Refseq: NP_001124388
• MIM: 190181
• Uniprot ID: P36897
• Chromosome Location: 9q22
• Pathway: ALK1 signaling events, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem
• Function: ATP binding; I-SMAD binding; SMAD binding; SMAD binding; contributes_to growth factor binding