"TGFBR1" Related Products

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Recombinant Human TGFBR1

Cat.No. : TGFBR1-31137TH
Product Overview : Recombinant fragment of Human TGF beta Receptor I with N-terminal proprietary tag, 424 amino acids, MWt 66kDa.
Description : The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
Protein length : 424 amino acids
Molecular Weight : 66.000kDa inclusive of tags
Source : Baculovirus infected sf9 cells
Tissue specificity : Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
Biological activity : The Specific activity of TGFBR1-31137TH was determined to be 3 nmol/min/mg.
Form : Liquid
Purity : Densitometry
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 GS domain.Contains 1 protein kinase domain.
Gene Name : TGFBR1 transforming growth factor, beta receptor 1 [ Homo sapiens ]
Official Symbol : TGFBR1
Synonyms : TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5;
Gene ID : 7046
mRNA Refseq : NM_001130916
Protein Refseq : NP_001124388
MIM : 190181
Uniprot ID : P36897
Chromosome Location : 9q22
Pathway : ALK1 signaling events, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem;
Function : ATP binding; I-SMAD binding; SMAD binding; SMAD binding; contributes_to growth factor binding;

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