"TGFBR1" Related Products

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Recombinant Human TGFBR1

Cat.No.: TGFBR1-31138TH
Product Overview: Recombinant fragment, corresponding to amino acids 80-426 of Human TGF beta Receptor I was expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 65kDa.
Description: The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
Tissue specificity: Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 GS domain.Contains 1 protein kinase domain.
Gene Name: TGFBR1 transforming growth factor, beta receptor 1 [ Homo sapiens ]
Official Symbol: TGFBR1
Synonyms: TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5;
Gene ID: 7046
mRNA Refseq: NM_001130916
Protein Refseq: NP_001124388
MIM: 190181
Uniprot ID: P36897
Chromosome Location: 9q22
Pathway: ALK1 signaling events, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem;
Function: ATP binding; I-SMAD binding; SMAD binding; SMAD binding; contributes_to growth factor binding;

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