|Product Overview :
||Recombinant fragment, corresponding to amino acids 80-426 of Human TGF beta Receptor I was expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 65kDa.
||The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
|Tissue specificity :
||Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
||>90% by SDS-PAGE
|Storage buffer :
||Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5
||Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequence Similarities :
||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 GS domain.Contains 1 protein kinase domain.