Recombinant Human THRA, His-tagged
Cat.No. : | THRA-31520TH |
Product Overview : | Recombinant full length Human Thyroid Hormone Receptor alpha 1, with His tag expressed in a baculovirus system, approximately 54kDa, amino acids 1-490, |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Conjugation : | HIS |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Gene Name : | THRA thyroid hormone receptor, alpha [ Homo sapiens ] |
Official Symbol : | THRA |
Synonyms : | THRA; thyroid hormone receptor, alpha; ERBA1, THRA1, THRA2, thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v erb a) oncogene homolog) , thyroid hormone receptor, alpha (erythroblastic leukemia viral (v erb a) oncogene homolog, avi |
Gene ID : | 7067 |
mRNA Refseq : | NM_001190918 |
Protein Refseq : | NP_001177847 |
MIM : | 190120 |
Uniprot ID : | P10827 |
Chromosome Location : | 17q21.1 |
Pathway : | Endochondral Ossification, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; |
Function : | TBP-class protein binding; metal ion binding; protein binding; protein domain specific binding; receptor activity; |
Products Types
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THRA-1198H | Active Recombinant Human THRA, His-tagged | +Inquiry |
◆ Lysates | ||
THRA-1090HCL | Recombinant Human THRA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe activity of the THRA protein can be modulated by drugs or other small molecule compounds to treat diseases related to the THRA protein. For example, some drugs can inhibit the activity of the THRA protein to treat diseases such as hyperthyroidism.
The THRA protein has some association with other hormones or signaling molecules. For example, it can interact with other hormones such as glucocorticoids and sex hormones to co-regulate the expression of target genes. In addition, it can interact with other signaling molecules, such as the MAPK signaling pathway.
Some studies have shown that abnormal expression of THRA protein may be related to the occurrence and progression of some diseases, such as thyroid disease, autoimmune diseases, etc. In addition, THRA proteins may also be drug targets for the treatment of these diseases.
Biological significance of THRA protein in the human body is to regulate the physiological function of thyroid hormones. It can mediate its signal transduction through binding to thyroid hormones to maintain the body's metabolic balance and growth and development.
Interaction between THRA proteins and other nuclear receptors or proteins is complex. For example, it can interact with other thyroid hormone receptors (THRB and THRG) to form heterodimers that co-regulate the expression of target genes. In addition, it can interact with regulatory factors, affecting their activity.
Activity of THRA protein is regulated by a variety of factors, including the concentration of ligands (thyroid hormones), phosphorylation modifications, small molecule regulators, etc. These factors can affect the DNA binding capacity, transcriptional activation and ligand binding capacity of THRA proteins, thereby regulating their activity.
Customer Reviews (3)
Write a reviewThe stability of THRA is highly appreciated, and its ability to maintain stable properties even after multiple freeze-thaw cycles is very valuable in practical applications.
The short half-life and high clearance of THRA make it a promising candidate for new generation of therapeutic drugs.
This production process of THRA is truly green and environmentally friendly, with little impact on the environment.
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