"TIMP2" Related Products

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Recombinant Human TIMP2

Cat.No.: TIMP2-29289TH
Product Overview: Recombinant full length Human TIMP2; amino acids 27-220 , 21.8kDa.
Description: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Source: E. coli
Biological activity: Biological Activity :TIMP2 activity was measured by its ability to inhibit human MMP1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP2 concentration of approximately 0.5 μg/ml, when
Form: Lyophilised
Purity: >95% by SDS-PAGE
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MCSCSPVHPQ QAFCNADVVI RAKAVSEKEV DSGNDIYGNP IKRIQYEIKQ IKMFKGPEKD IEFIYTAPSS AVCGVSLDVG GKKEYLIAGK AEGDGKMHIT LCDFIVPWDT LSTTQKKSLN HRYQMGCECK ITRCPMIPCY ISSPDECLWM DWVTEKNING HQAKFFACIK RSDGSCAWYR GAAPPKQEFL DIEDP
Sequence Similarities: Belongs to the protease inhibitor I35 (TIMP) family.Contains 1 NTR domain.
Gene Name: TIMP2 TIMP metallopeptidase inhibitor 2 [ Homo sapiens ]
Official Symbol: TIMP2
Synonyms: TIMP2; TIMP metallopeptidase inhibitor 2; tissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; CSC 21K;
Gene ID: 7077
mRNA Refseq: NM_003255
Protein Refseq: NP_003246
MIM: 188825
Uniprot ID: P16035
Chromosome Location: 17q25
Pathway: Matrix Metalloproteinases, organism-specific biosystem;
Function: enzyme activator activity; enzyme inhibitor activity; integrin binding; metal ion binding; metalloendopeptidase inhibitor activity;

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