||Recombinant full length Human TNF alpha expressed in modified human 293 cells; 15-20kDa.
||This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
||The ED50 of TNF alpha is typically 0.04-0.06 ng/ml as measured in cytotoxicity assay using the TNF alpha susceptible murine WEHI 164 cell line in the presence of actinomycin D.
||>95% by SDS-PAGE
||Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin, PBS
||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||Theoretical sequence:VRSSSRTPSDKPVAHVVANPQAEGQLQWL NRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQ GCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPE GAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFA ESGQVYFGIIAL
||Belongs to the tumor necrosis factor family.