"TNFRSF10B" Related Products

Expand
Expand
Expand

Recombinant Human TNFRSF10B, Fc-tagged

Cat.No.: TNFRSF10B-28129TH
Product Overview: Recombinant fragment of the extracellular domain of Human DR5 fused to the Fc portion of Human IgG1, 52kDa.
Description: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
Protein length: 216 amino acids
Conjugation: Fc
Molecular Weight: 52.000kDa inclusive of tags
Source: HEK 293 cells
Tissue specificity: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 and G361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, p
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: PBS
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities: Contains 1 death domain.Contains 3 TNFR-Cys repeats.
Gene Name: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [ Homo sapiens ]
Official Symbol: TNFRSF10B
Synonyms: TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB;
Gene ID: 8795
mRNA Refseq: NM_003842
Protein Refseq: NP_003833
MIM: 603612
Uniprot ID: O14763
Chromosome Location: 8p22-p21
Pathway: Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem;
Function: TRAIL binding; cysteine-type endopeptidase activator activity involved in apoptotic process; protein binding; receptor activity;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.