Recombinant Human TNFRSF9, Fc-tagged

• Cat.No.: TNFRSF9-27833TH
• Product Overview: Recombinant fragment corresponding to amino acids 1-186 of Human CD137 fused to the Fc portion fused to the C-terminus of Human IgG1; MWt 50 kDa .

Specification

• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
• Protein length: 186 amino acids
• Conjugation: Fc
• Molecular Weight: 50.000kDa inclusive of tags
• Source: HEK 293 cells
• Tissue specificity: Expressed on the surface of activated T-cells.
• Form: Lyophilised:Reconstitute with 50μl sterile water to give a final concentration of 1mg/ml. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS
• Storage: Shipped at 4°C. Store at -20oC.
• Sequence Similarities: Contains 4 TNFR-Cys repeats.

Gene Information

• Gene Name: TNFRSF9 tumor necrosis factor receptor superfamily, member 9 [ Homo sapiens ]
• Official Symbol: TNFRSF9
• Synonyms: TNFRSF9; tumor necrosis factor receptor superfamily, member 9; ILA; tumor necrosis factor receptor superfamily member 9; 4 1BB; CD137
• Gene ID: 3604
• mRNA Refseq: NM_001561
• Protein Refseq: NP_001552
• MIM: 602250
• Uniprot ID: Q07011
• Chromosome Location: 1p36
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem
• Function: binding; receptor activity