Recombinant Human TPMT

• Cat.No.: TPMT-30640TH
• Product Overview: Recombinant full length TPMT protein , 245aa, MW ~28kDa.

Specification

• Description: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20mM Tris, 2mM EDTA, 0.2mM PMSF, pH 8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLKKHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFFTEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIWDRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVPHAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK
• Sequence Similarities: Belongs to the methyltransferase superfamily. TPMT family.

Gene Information

• Gene Name: TPMT thiopurine S-methyltransferase [ Homo sapiens ]
• Official Symbol: TPMT
• Synonyms: TPMT; thiopurine S-methyltransferase
• Gene ID: 7172
• mRNA Refseq: NM_000367
• Protein Refseq: NP_000358
• MIM: 187680
• Uniprot ID: P51580
• Chromosome Location: 6p22.3
• Pathway: Biological oxidations, organism-specific biosystem; Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Metabolism, organism-specific biosystem; Methylation, organism-specific biosystem
• Function: methyltransferase activity; thiopurine S-methyltransferase activity; transferase activity