"TPO" Related Products


Recombinant Human TPO, His-tagged

Cat.No.: TPO-29616TH
Product Overview: Recombinant fragment of Human Thyroid Peroxidase produced in Sf9 insect cells with 6x His-tag; 834 amino acids, 101 kDa total mass.
Description: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
Conjugation: HIS
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 160mM Sodium chloride, 16mM HEPES, 0.08mM Kl, pH 7.6
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Belongs to the peroxidase family. XPO subfamily.Contains 1 EGF-like domain.Contains 1 Sushi (CCP/SCR) domain.
Gene Name: TPO thyroid peroxidase [ Homo sapiens ]
Official Symbol: TPO
Synonyms: TPO; thyroid peroxidase; TPX;
Gene ID: 7173
mRNA Refseq: NM_000547
Protein Refseq: NP_000538
MIM: 606765
Uniprot ID: P07202
Chromosome Location: 2p25
Pathway: Amine-derived hormones, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function: calcium ion binding; heme binding; iodide peroxidase activity; oxidoreductase activity; peroxidase activity;

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