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Recombinant Human TTK

Cat.No.: TTK-29701TH
Product Overview: Recombinant full length Human Mps1 with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system; MWt 130kDa.
Description: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
Biological activity: The Specific activity of TTK-29701TH was determined to be 19 nmol/min/mg.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name: TTK TTK protein kinase [ Homo sapiens ]
Official Symbol: TTK
Synonyms: TTK; TTK protein kinase; dual specificity protein kinase TTK; cancer/testis antigen 96; CT96; MPS1L1;
Gene ID: 7272
mRNA Refseq: NM_001166691
Protein Refseq: NP_001160163
MIM: 604092
Uniprot ID: P33981
Chromosome Location: 6q13-q21
Pathway: Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem;
Function: ATP binding; nucleotide binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity;

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