"TTR" Related Products

Recombinant Human TTR

Cat.No.: TTR-31110TH
Product Overview: Recombinant full length Human Prealbumin; amino acids 21-147, 128 amino acids, MWt 13.8 kDa.
Description: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Source: E. coli
Tissue specificity: Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, PBS, pH 7.4
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGPTGTGESK CPLMVKVLDA VRGSPAINVA VHVFRKAADD TWEPFASGKT SESGELHGLT TEEEFVEGIY KVEIDTKSYW KALGISPFHE HAEVVFTAND SGPRRYTIAA LLSPYSYSTT AVVTNPKE
Sequence Similarities: Belongs to the transthyretin family.
Gene Name: TTR transthyretin [ Homo sapiens ]
Official Symbol: TTR
Synonyms: TTR; transthyretin; PALB, prealbumin, amyloidosis type I; HsT2651;
Gene ID: 7276
mRNA Refseq: NM_000371
Protein Refseq: NP_000362
MIM: 176300
Uniprot ID: P02766
Chromosome Location: 18q12.1
Pathway: Amyloids, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem;
Function: hormone activity; hormone binding; protein binding;

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