Recombinant Human TTR
Cat.No. : | TTR-31111TH |
Product Overview : | Recombinant full length Human Prealbumin expressed in Saccharomyces cerevisiae; MWt 15.9 kDa. Protein is tagged with a 26 kDa proprietary tag. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. |
Tissue specificity : | Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MASHRLLLLCLAGLVFVSEAGPTGT GESKCPLMVKVLDAV RGSPAINVAVHVFRKAADDTWEPFA SGKTSESGELHGL TTEEEFVEGIYKVEIDTKSYWKALG ISPFHEHAEVVFTANDSGPRRYTIA ALLSPYSYSTTAVVTNPKE |
Sequence Similarities : | Belongs to the transthyretin family. |
Gene Name : | TTR transthyretin [ Homo sapiens ] |
Official Symbol : | TTR |
Synonyms : | TTR; transthyretin; PALB, prealbumin, amyloidosis type I; HsT2651; |
Gene ID : | 7276 |
mRNA Refseq : | NM_000371 |
Protein Refseq : | NP_000362 |
MIM : | 176300 |
Uniprot ID : | P02766 |
Chromosome Location : | 18q12.1 |
Pathway : | Amyloids, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; |
Function : | hormone activity; hormone binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
TTR-6008R | Recombinant Rat TTR Protein, His (Fc)-Avi-tagged | +Inquiry |
TTR-802C | Recombinant Cynomolgus Monkey TTR Protein, His (Fc)-Avi-tagged | +Inquiry |
TTR-04H | Recombinant Human TTR (L55P) Protein (Full Length) | +Inquiry |
TTR-9747M | Recombinant Mouse TTR Protein, His (Fc)-Avi-tagged | +Inquiry |
TTR-2774H | Recombinant Human TTR Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
TTR-155B | Native Bovine Prealbumin protein | +Inquiry |
TTR-141S | Native Sheep prealbumin | +Inquiry |
TTR-254H | Native Human Prealbumin | +Inquiry |
◆ Lysates | ||
TTR-2149HCL | Recombinant Human TTR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionTTR is involved in the transport of thyroxine and retinol and plays a role in processes such as protein degradation.
RAGE proteins interact with TTR proteins and are involved in the regulation of TRR expression.
TTR proteins are highly conserved and are found in several vertebrates, such as humans, rats, sheep, and chickens.
TTR is mainly synthesized in the liver.
TTR is associated with a variety of diseases including amyloidosis TTR (ATTR), dementia (AD) and neurological damage.
Customer Reviews (3)
Write a reviewTimely delivery, so I got the desired experimental results in the shortest possible time.
I have a dedicated staff member who contacts me and keeps me informed on the progress of custom protein production.
The purchased product information is in line with the advertising campaign and is conducive to obtaining accurate experimental results.
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