Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human TTR

Cat.No. : TTR-31111TH
Product Overview : Recombinant full length Human Prealbumin expressed in Saccharomyces cerevisiae; MWt 15.9 kDa. Protein is tagged with a 26 kDa proprietary tag.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Tissue specificity : Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids : MASHRLLLLCLAGLVFVSEAGPTGT GESKCPLMVKVLDAV RGSPAINVAVHVFRKAADDTWEPFA SGKTSESGELHGL TTEEEFVEGIYKVEIDTKSYWKALG ISPFHEHAEVVFTANDSGPRRYTIA ALLSPYSYSTTAVVTNPKE
Sequence Similarities : Belongs to the transthyretin family.
Gene Name : TTR transthyretin [ Homo sapiens ]
Official Symbol : TTR
Synonyms : TTR; transthyretin; PALB, prealbumin, amyloidosis type I; HsT2651;
Gene ID : 7276
mRNA Refseq : NM_000371
Protein Refseq : NP_000362
MIM : 176300
Uniprot ID : P02766
Chromosome Location : 18q12.1
Pathway : Amyloids, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem;
Function : hormone activity; hormone binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
What are the main physiologic functions of TTR? 07/14/2022

TTR is involved in the transport of thyroxine and retinol and plays a role in processes such as protein degradation.

How are RAGE proteins related to TTR proteins? 11/23/2021

RAGE proteins interact with TTR proteins and are involved in the regulation of TRR expression.

In which animals is TTR expressed? 06/07/2021

TTR proteins are highly conserved and are found in several vertebrates, such as humans, rats, sheep, and chickens.

Where is TTR primarily synthesized? 03/05/2021

TTR is mainly synthesized in the liver.

TTR is closely linked to research on what diseases 10/22/2020

TTR is associated with a variety of diseases including amyloidosis TTR (ATTR), dementia (AD) and neurological damage.

Customer Reviews (3)

Write a review
Reviews
07/14/2022

    Timely delivery, so I got the desired experimental results in the shortest possible time.

    11/26/2021

      I have a dedicated staff member who contacts me and keeps me informed on the progress of custom protein production.

      01/02/2021

        The purchased product information is in line with the advertising campaign and is conducive to obtaining accurate experimental results.

        Ask a Question for All TTR Products

        Required fields are marked with *

        My Review for All TTR Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends