Native Human UMOD


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Native Human UMOD

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Cat.No. : UMOD-31076TH
Product Overview : Full length native Human Uromucoid purified from urine from healthy individuals; amino acids 25-614 predicted MWt 64kDa actual 80kDa.
Description : This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Protein length : 590 amino acids
Molecular Weight : 64.000kDa
Tissue specificity : Synthesized by kidney. Most abundant protein in normal human urine.
Form : Lyophilised:Use of de-ionised water is recommended
Storage buffer : Preservative: NoneConstituents: dH2O
Storage : Store at +4°C.
Sequence Similarities : Contains 3 EGF-like domains.Contains 1 ZP domain.
Gene Name : UMOD uromodulin [ Homo sapiens ]
Official Symbol : UMOD
Synonyms : UMOD; uromodulin; uromodulin (uromucoid, Tamm Horsfall glycoprotein); Tamm Horsfall glycoprotein; uromucoid;
Gene ID : 7369
mRNA Refseq : NM_001008389
Protein Refseq : NP_001008390
MIM : 191845
Uniprot ID : P07911
Chromosome Location : 16p12.3
Function : calcium ion binding;

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